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Cardinals beat Chargers in NFL's biggest upset of Week 1

Arizona Cardinals, Los Angeles Chargers

Latest report: September 13, 2026 at 7:24 PM EDT

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Headline: Cardinals beat Chargers in NFL's biggest upset of Week 1

Description: The Chargers were the NFL's biggest favorites, with a 9.5-point spread. Instead, the Cardinals won 26-14.

Published: September 13, 2026 at 7:24 PM EDT

Source: https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/cardinals-beat-chargers-in-nfls-biggest-upset-of-week-1